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Research Outcomes

ROI researchers are generating results that are advancing practice and improving outcomes for patients. Innovative clinicians developed the resources listed below with grants supported by ROI donors, and thousands of providers are using them to enhance patient care.

CEBRE Lung Handout

CEBRE Discussion Guides

Daniel Golden, MD, MHPE, of the University of Chicago has led the development of the “Communicating the External Beam Radiotherapy Experience” (CEBRE) series of discussion guides to facilitate conversations between patients and providers. With support from ROI, Dr. Golden’s team has developed CEBRE guides about radiotherapy for breast, central nervous system, digestive system, head and neck, lung, and prostate cancers. See a preview of each of the personalized discussion guides below and download the entire series for clinical use free of charge on the CEBRE website.

Dr. Golden's team has also translated the breast, lung, and prostate cancer discussion guides into Spanish. Download the guides from the CEBRE en Español website.

RadOnc Toolbox App

The RadOnc Toolbox App puts evidence-based guidelines and other point-of-care resources at your fingertips. With support from the ROI, Malolan Rajagopalan, MD, MBA, originally developed the app to compile and categorize evidence-based symptom management strategies for eight of the most common radiation toxicities. The RadOnc Toolbox app also includes dose constraints, calculators, ASTRO Clinical Guideline summaries, and other practical tools. Download the RadOnc Toolbox for free on the:


ROI researchers have published the results of their ROI-supported projects in the following manuscripts. The most recent articles are listed first.

Avila S, Franco I, Bregio C, et al. Spanish Adaptation and Evaluation of Clinical Discussion Guides: Communicating the External Beam Radiotherapy Experience (CEBRE) en EspañolInt J Radiat Oncol Biol Phys. Published online January 27, 2023. doi: 10.1016/j.ijrobp.2023.01.031. 

Mattes MD, Munoz SM, Thomas CR, and Deville C. Pilot Study Exploring the Feasibility of Incorporating Radiation Oncology into Preexisting Early Pathway Programs for Diverse Premedical StudentsInt J Radiat Oncol Biol Phys. Published online January 22, 2023. doi: 10.1016/j.ijrobp.2023.01.023. 

Mattes MD, Gayed G, Thomas CR, and Deville C. Impact of a Virtual Introduction to Radiation Oncology Presentation on Stimulating Interest in the Specialty Among Diverse Medical Students at Multiple InstitutionsJ Am Coll Radiol. Published online December 9, 2022. doi: 10.1016/j.jacr.2022.10.009.

Paradis KC, Franco I, Ponce SB, et al. The Current State of Departmental Diversity, Equity, and Inclusion Efforts Within US Academic Radiation Oncology DepartmentsInt J Radiat Oncol Biol Phys. Published online October 25, 2022. doi: 10.1016/j.ijrobp.2022.06.071.

Kishan AU, Steigler A, Denham JW, et al. Interplay between duration of androgen deprivation therapy and external beam radiotherapy with or without a brachytherapy boost for optimal treatment of high-risk prostate cancer: A patient-Level data analysis of 3 cohortsJAMA Oncol. Published online January 20, 2022. doi:10.1001/jamaoncol.2021.6871.

Mattes M & Deville C. A survey to assess and delineate approaches to medical student outreach to promote diversity at academic radiation oncology programs. Int J Radiat Oncol Biol Phys. Published online January 7, 2022.

Ibrahim EH, Frank L, Baruah D, et al. Value CMR: Towards a comprehensive, rapid, cost-effective cardiovascular magnetic resonance imaging. Int J Biomed Imaging. 2021; 2021. doi: 10.1155/2021/8851958.

Qu XM, Chen Y, Zaric GS, et al. Is SABR cost-effective in oligometastatic cancer? An economic analysis of the SABR-COMET randomized trial. Int J Radiat Oncol Biol Phys. 2021; 109(5): 1176-1184.

Tang C, Lei X, Smith GL, et al. Influence of geography on prostate cancer treatment. Int J Radiat Oncol Biol Phys. 2021; 109(5): 1286-1295.

Guo Y, Jiang W, Lakshminarayanan P, et al. Spatial radiation dose influence on xerostomia recovery and its comparison to acute incidence in head neck cancer patients. Adv Radiat Oncol. 2020; 5(2): 221-230. doi: 10.1016/j.adro.2019.08.009.

Nugent SM, Golden SE, Hooker ER, et al. Longitudinal health-related quality of life among individuals considering treatment for stage I non-small-cell lung cancer. Ann Am Thorac Soc. 2020; 17(8): 988-997.

Paul S, Bodner WR, Garg M, Tang J, Ohri N. Cardiac irradiation predicts activity decline in patients receiving concurrent chemoradiation for locally advanced lung cancer. Int J Radiat Oncol Biol Phys. 2020; 108(3): 597-601.

Tang C, Lei X, Smith GL, et al. Costs and complications after a diagnosis of prostate cancer treated with time-efficient modalities: An analysis of national Medicare data. Pract Radiat Oncol. 2020; 10(4): 282-292.

Wolfe AR, Wald P, Webb A, et al. A microRNA-based signature predicts local-regional failure and overall survival after pancreatic cancer resection. Oncotarget. 2020; 11: 913-923.

Han P, Lakshminarayanan P, Jiang W, et al. Dose/Volume histogram patterns in salivary gland subvolumes influence xerostomia injury and recovery. Sci Rep. 2019; 9. doi: 10.1038/s41598-019-40228-y.

Lakshminarayanan P, Jiang W, Robertson SP, et al. Radio-morphology: Parametric shape-based features in radiotherapy. Med Phys. 2019; 46(2): 704-713.

Ohri N, Halmos B, Bodner R, et al. Daily step counts: A new prognostic factor in locally advanced non-small cell lung cancer? Int J Radiat Oncol Biol Phys. 2019; 105(4): 745-751.

Sheikh K, Lee SH, Cheng Z, et al. Predicting acute radiation induced xerostomia in head and neck cancer using MR and CT Radiomics of parotid and submandibular glands. Radiat Oncol. 2019; 14. doi: 10.1186/s13014-019-1339-4.

Sher DJ, Yan J, Day A, et al. Comparative effectiveness of primary radiotherapy versus surgery in elderly patients with locally advanced oropharyngeal squamous cell carcinoma. Oral Oncol. 2019; 88: 18-26.

Sullivan DR, Eden KB, Dieckmann NF, et al. Understanding patients’ values and preferences regarding early stage lung cancer treatment decision making. Lung Cancer. 2019; 131: 47-57.

Jiang W, Lakshminarayanan P, Hui X, et al. Machine learning methods uncover radio-morphologic dose patterns in salivary glands that predict xerostomia in head and neck cancer patients. Adv Radiat Oncol. 2019; 4(2): 401-412.

Nugent SM, Golden SE, Thomas CR, et al. Patient-clinician communication among patients with stage I lung cancer. Support Care Cancer. 2018; 26: 1625–1633.

Sher DJ, Agiro A, Zhou S, Day AT, DeVries A. Commercial claims–based comparison of survival and toxic effects of definitive radiotherapy vs primary surgery in patients with oropharyngeal squamous cell carcinoma. JAMA Otolaryngol Head Neck Surg. 2018;144(10):913–922.

Golden SE, Thomas CR, Deffebach ME, et al. “It wasn’t as bad as I thought it would be”: a qualitative study of early stage non-small cell lung cancer patients after treatment. BMC Res Notes. 2017; 10. doi: 10.1186/s13104-017-2956-3.

Golden SE, Thomas CR, Moghanaki D, Slatore CG. Dumping the information bucket: A qualitative study of clinicians caring for patients with early stage non-small cell lung cancer. Patient Educ Couns. 2017; 100(5): 861-870.

Fuangrod T, Greer PB, Woodruff HC, et al. Investigation of a real-time EPID-based patient dose monitoring safety system using site-specific control limits. Radiat Oncol. 2016; 11. doi: 10.1186/s13014-016-0682-y.

Golden SE, Thomas CR, Deffebach ME, et al. "Even if I don't remember, I feel better". A qualitative study of patients with early-stage non-small cell lung cancer undergoing stereotactic body radiotherapy or surgery. Ann Am Thorac Soc. 2016; 13(8): 1361-1369.

Woodruff HC, Fuangrod T, Van Uytven E, et al. First experience with real-time EPID based delivery verification during IMRT and VMAT treatments. Int J Radiat Oncol Biol Phys. 2015; 93(3): 516-522.

Fuangrod T, Rowshanfarzad P, Greer PB, Middleton RH. A cine-EPID based method for jaw detection and quality assurance for tracking jaw in IMRT/VMAT treatments. Physica Medica. 2014; 31(1): 16-24.